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Implications of activation of Soluble Guanylate Cyclase (sGC). NO... | Download Scientific Diagram

Furthermore, pre-treatment with mitochondrial protective agent dimethyl fumerate (DMF) and elamipretide (SS-31) prior to GA exposure prevented ISO induced activation of ferroptosis in P7 mice, as well as abrogated learning and cognitive deficits, supporting mitochondrial involvement as a key component of ferroptosis activation following GA exposure and PAN (87, 154)

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Its role in the adult brain involves supporting neuronal survival, promoting synaptic plasticity, and facilitating neurogenesis -- functions that make it a plausible target for cognitive enhancement